FASCINATION ABOUT METHADONE WAFERS

[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, that is fewer potent as an opioid, is more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone has a lower affinity, with an IC50 of ~29 μM in th